"We can confirm that there's one fatality at the scene," McCormick said.
Vehicles were being detoured off the highway at Exit 24, causing heavy traffic congestion on the Northway and a number of surface streets in Albany, Colonie and Guilderland.
The crash is under investigation, with accident reconstruction specialists on-site.
All westbound lanes of the Thruway were closed after the crash with one eastbound lane remaining open, McCormick said.
Fire trucks and police were trying to get to the crash scene at 10:45 a.m.aside">